Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 4/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912802 | 0.81 | SIRT6 (0.50) | DHFRPOLBTYMS | |
| SCHEMBL8912815 | 0.77 | TSHR (0.57) | TYMS | |
| SCHEMBL8912282 | 0.71 | DRD4 (0.43) | DHFRXDHNOS1 | |
| SCHEMBL8911693 | 0.71 | TTR (0.47) | DHFRGFERPOLBXDHNOS1 | |
| SCHEMBL12294725 | 0.71 | HRH3 (0.48) | GFER | |
| SCHEMBL17876410 | 0.70 | ADRB1 (0.52) | DHFRGFERPOLB | |
| SCHEMBL8167418 | 0.69 | DHFR (0.67) | DHFR | |
| SCHEMBL8911701 | 0.69 | NOS1 (0.47) | DHFRGFERPOLBPKMXDH | |
| SCHEMBL8912435 | 0.68 | DHFR (0.40) | DHFRGFERPOLBPKMXDH | |
| SCHEMBL111714 | 0.66 | GAA (0.62) | GFERFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670508-A | ANTITUMOR AGENTS FOR BRAIN TUMORS | NATIONAL SCIENCE COUNCIL (TW) | 1997-09-23 | — | — | US | disclosed |