Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 8/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 4/20 | 0.46 |
| ▸ | MMP3 | P08254 | 3/20 | 0.46 |
| ▸ | MMP13 | P45452 | 3/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP7 | P09237 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8914320 | 0.90 | BCAT2 (0.45) | KDM4EALDH1A1CASP1NPSR1HSD17B10 | |
| SCHEMBL8913470 | 0.83 | HTT (0.50) | KDM4EALDH1A1ADAMTS4MMP2MMP3 | |
| SCHEMBL8912797 | 0.81 | SLC1A3 (0.47) | KDM4EALDH1A1HPGDCASP1CASP7 | |
| SCHEMBL8914187 | 0.81 | ADAMTS4 (0.66) | ADAMTS4MMP2MMP3MMP13MMP1 | |
| SCHEMBL8913118 | 0.76 | MMP2 (0.67) | ADAMTS4SLC1A3SLC1A2SLC1A1MMP2 | |
| SCHEMBL8914335 | 0.76 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDCASP1CASP7 | |
| SCHEMBL8913335 | 0.71 | KCNA5 (0.47) | ADAMTS4SLC1A3SLC1A2SLC1A1MMP1 | |
| SCHEMBL10965358 | 0.69 | F2 (0.53) | KDM4EALDH1A1HPGDCASP1CASP7 | |
| SCHEMBL10966272 | 0.69 | F2 (0.53) | KDM4EALDH1A1HPGDCASP1CASP7 | |
| SCHEMBL8913990 | 0.69 | ADAMTS4 (0.64) | ALDH1A1HSD17B10ADAMTS4SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |
| WO-1993005014-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO-WEDROPHARM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |