SCHEMBL8914727

SCHEMBL8914727

C[SiH](C)c1ccc(C(=O)O)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.63
TP53 P04637 1/20 0.63
ALDH1A1 P00352 2/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
SRD5A2 P31213 4/20 0.55
CA1 P00915 3/20 0.52
CA2 P00918 3/20 0.52
CA12 O43570 1/20 0.52
CA3 P07451 1/20 0.52
TYR P14679 1/20 0.52
DRD1 P21728 1/20 0.52
CA4 P22748 1/20 0.52
CA6 P23280 1/20 0.52
CA5A P35218 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
CA14 Q9ULX7 1/20 0.52
CA5B Q9Y2D0 1/20 0.52
ALOX15 P16050 1/20 0.50
DAO P14920 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27893882 0.93 BCL2L1 (0.56) TSHRTP53ALDH1A1SMN1; SMN2SRD5A2
Biphenyl SCHEMBL8913858 0.89 EGFR (0.53) TSHRTP53SMN1; SMN2SRD5A2DAO
SCHEMBL15873969 0.84 SRD5A2 (0.55) TSHRTP53ALDH1A1SRD5A2HPGD
SCHEMBL19194632 0.82 HPGD (0.56) ALDH1A1SMN1; SMN2HPGD
SCHEMBL8915552 0.80 ALDH1A1 (0.43) TSHRTP53ALDH1A1SMN1; SMN2SRD5A2
Terephthalic Acid SCHEMBL1403607 0.80 TSHR (0.86) TSHRTP53ALDH1A1SMN1; SMN2SRD5A2
Terephthalic Acid SCHEMBL11416580 0.80 TSHR (0.86) TSHRTP53ALDH1A1SMN1; SMN2SRD5A2
Terephthalic Acid SCHEMBL1403625 0.80 TSHR (0.86) TSHRTP53ALDH1A1SMN1; SMN2SRD5A2
Terephthalic Acid SCHEMBL175823 0.80 TSHR (1.00) TSHRTP53ALDH1A1SMN1; SMN2SRD5A2
Terephthalic Acid SCHEMBL1655 0.80 TSHR (1.00) TSHRTP53ALDH1A1SMN1; SMN2SRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105899581-B Transparent polyamide-imide resin and film using the same 可隆工业株式会社 2017-11-24 CN claimed
CN-105899581-A Transparent polyamide-imide resin and film using the same 可隆工业株式会社 2016-08-24 CN claimed
US-10414903-B2 Methods for synthesis of end-functionalized polyolefins THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2019-09-17 US disclosed
US-10414903-B2 Methods for synthesis of end-functionalized polyolefins THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2019-09-17 US disclosed
US-20180134873-A1 METHODS FOR SYNTHESIS OF END-FUNCTIONALIZED POLYOLEFINS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2018-05-17 US disclosed
US-20180134873-A1 METHODS FOR SYNTHESIS OF END-FUNCTIONALIZED POLYOLEFINS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2018-05-17 US disclosed
US-20180134873-A1 METHODS FOR SYNTHESIS OF END-FUNCTIONALIZED POLYOLEFINS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2018-05-17 US disclosed
CN-105899581-B Transparent polyamide-imide resin and film using the same 可隆工业株式会社 2017-11-24 CN disclosed
CN-105899581-A Transparent polyamide-imide resin and film using the same 可隆工业株式会社 2016-08-24 CN disclosed
WO-2015106294-A1 BIVALENT BCR-ABL TYROSINE KINASE LIGANDS, AND METHODS OF USING SAME COFERON,INC. (US) 2015-07-16 WO disclosed
US-RE35462-E Silylated benzoic acid derivatives CONSORTIUM FUR ELEKOCHEMISCHE IND. GMBH (DE) 1997-02-25 US disclosed
US-5221759-A CYCLOSILOXANES CONTAINING MESOGENIC SIDE GROUPS CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1993-06-22 US disclosed
US-5210247-A ORGANOSILYLALKYLAROMATIC COMPOUNDS CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1993-05-11 US disclosed
US-5158702-A SILYLATED BENZOIC ACID DERIVATIVES II CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1992-10-27 US disclosed
US-5106530-A Liquid crystals Consortium Fur Elektrochemische Ind. (DE) 1992-04-21 US disclosed
EP-0466183-A1 Cyclosiloxanes with mesogenic side groups Consortium für elektrochemische Industrie GmbH (DE) 1992-01-15 EP disclosed
US-5070179-A PRIMERS HAVING GOOD ADHESION AND FRICTION COEFFICIENT CHEIL SYNTHETICS INC. (KR) 1991-12-03 US disclosed
EP-0405326-A2 Silylated benzoic acid derivatives Consortium für elektrochemische Industrie GmbH (DE) 1991-01-02 EP disclosed
EP-0404140-A2 Silylated benzoic acid derivatives II Consortium für elektrochemische Industrie GmbH (DE) 1990-12-27 EP disclosed
US-4914221-A Dimethylsilyl-substituted benzoyl chlorides and a process for preparing the same CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1990-04-03 US disclosed