Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.49 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874936 | 0.89 | PTGS2 (0.46) | PTGS2PTGS1EGLN1P4HTMEGFR | |
| SCHEMBL8767482 | 0.87 | PTGS2 (0.58) | PTGS2PTGS1P4HTMEGFRGAA | |
| SCHEMBL8916746 | 0.86 | EGLN1 (0.42) | PTGS2PTGS1EGLN1P4HTMEGFR | |
| Hydrochloric Acid SCHEMBL8915942 | 0.85 | PTGS2 (0.56) | PTGS2PTGS1P4HTMEGFRGAA | |
| SCHEMBL8875655 | 0.85 | PTGS2 (0.56) | PTGS2PTGS1P4HTMEGFRGAA | |
| SCHEMBL8915508 | 0.85 | EGLN1 (0.52) | EGLN1P4HTM | |
| SCHEMBL8875058 | 0.85 | MEN1 (0.45) | PTGS2PTGS1EGLN1P4HTMEGFR | |
| SCHEMBL8766943 | 0.85 | PTGS2 (0.48) | PTGS2PTGS1P4HTMEGFRGAA | |
| SCHEMBL8916898 | 0.84 | L3MBTL1 (0.52) | TDP1 | |
| SCHEMBL8917617 | 0.84 | LIMK1 (0.42) | PTGS2EGLN1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610172-A | Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-11 | — | — | US | claimed |
| US-5610172-A | Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-11 | — | — | US | disclosed |