Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916746 | 0.92 | EGLN1 (0.42) | LIMK1LIMK2CA1CA2CA9 | |
| SCHEMBL8875242 | 0.91 | LIMK1 (0.39) | LIMK1LIMK2CA2P4HTMKDM4E | |
| SCHEMBL8874117 | 0.86 | P4HTM (0.38) | LIMK1CA2P4HTMKDM4EALDH1A1 | |
| SCHEMBL8915935 | 0.84 | PTGS2 (0.51) | P4HTMEGLN1PTGS2 | |
| SCHEMBL8869660 | 0.84 | P4HTM (0.48) | LIMK1LIMK2CA1CA2CA9 | |
| SCHEMBL8875238 | 0.83 | MEN1 (0.44) | P4HTMSMPD1 | |
| SCHEMBL8768258 | 0.83 | CA1 (0.39) | LIMK1LIMK2CA1CA2CA9 | |
| SCHEMBL8875475 | 0.83 | P4HTM (0.39) | P4HTMALDH1A1PTGS2 | |
| SCHEMBL8875237 | 0.82 | P4HTM (0.38) | P4HTMEGLN1PTGS2 | |
| SCHEMBL8917435 | 0.82 | LMNA (0.38) | LIMK1LIMK2CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610172-A | Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-11 | — | — | US | disclosed |