Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917617 | 0.92 | LIMK1 (0.42) | EGLN1P4HTMLIMK1LIMK2PTGS2 | |
| SCHEMBL8875475 | 0.90 | P4HTM (0.39) | P4HTMCYP1A2HSP90AA1HSP90AB1BLM | |
| SCHEMBL8875237 | 0.90 | P4HTM (0.38) | EGLN1P4HTMCYP1A2HSP90AA1HSP90AB1 | |
| SCHEMBL8917435 | 0.90 | LMNA (0.38) | EGLN1P4HTMLMNAHPGDHTT | |
| SCHEMBL8918674 | 0.88 | EGLN1 (0.46) | EGLN1LMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL8875238 | 0.87 | MEN1 (0.44) | P4HTMCYP1A2HSP90AA1HSP90AB1BLM | |
| SCHEMBL8767162 | 0.87 | LMNA (0.40) | EGLN1P4HTMCYP1A2HSP90AA1HSP90AB1 | |
| SCHEMBL8915935 | 0.86 | PTGS2 (0.51) | EGLN1P4HTMPTGS2EGFRPTGS1 | |
| SCHEMBL8874117 | 0.84 | P4HTM (0.38) | P4HTMHTTSMN1; SMN2LIMK1PTGS2 | |
| SCHEMBL8875242 | 0.83 | LIMK1 (0.39) | P4HTMHTTSMN1; SMN2LIMK1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610172-A | Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-11 | — | — | US | disclosed |