Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | TACR2 | P21452 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | GALE | Q14376 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10079637 | 0.81 | KDM4E (0.50) | DHFRHTR2AHTR2CNR1I2ADRA2A | |
| SCHEMBL8917491 | 0.79 | ALDH1A1 (0.54) | HTR2CHTR6GLASMN1; SMN2LMNA | |
| SCHEMBL8918360 | 0.79 | MAPT (0.53) | GLASMN1; SMN2MAOATSHRTDP1 | |
| SCHEMBL10079674 | 0.79 | KDM4E (0.48) | DHFRHTR2AHTR2CNR1I2ADRA2A | |
| SCHEMBL5335767 | 0.78 | LMNA (0.47) | DHFRNR1I2ADRA2AOPRK1SLC6A3 | |
| Hydrochloric Acid SCHEMBL8615062 | 0.76 | DHFR (0.53) | DHFRHTR2AHTR2CNR1I2ADRA2A | |
| SCHEMBL5339875 | 0.76 | LMNA (0.49) | DHFRLMNATHRATHRBTSHR | |
| SCHEMBL12967934 | 0.75 | GLA (0.51) | DHFRHTR2AHTR2CNR1I2ADRA2A | |
| SCHEMBL8934074 | 0.75 | NR1I2 (0.46) | DHFRHTR2AHTR2CNR1I2ADRA2A | |
| SCHEMBL7975151 | 0.74 | L3MBTL1 (0.57) | DRD3KCNH2SMN1; SMN2TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696140-A | FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1997-12-09 | — | — | US | disclosed |