Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920714 | 0.92 | PTGS2 (0.46) | PTGS2NPBWR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9229223 | 0.91 | PTGS2 (0.40) | PTGS2PTGS1MAPT | |
| SCHEMBL8916244 | 0.90 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL8917392 | 0.90 | PTGS2 (0.57) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL8917741 | 0.83 | CA9 (0.52) | PTGS2PTGS1ALDH1A1MAPT | |
| SCHEMBL8916189 | 0.82 | PTGS2 (0.52) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL9234798 | 0.82 | PTGS2 (0.52) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL8918689 | 0.80 | PTGS2 (0.51) | PTGS2PTGS1CYP1A2 | |
| SCHEMBL8918668 | 0.76 | CA12 (0.46) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL8917550 | 0.76 | PTGS2 (0.40) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696143-A | ARTHRITIS THERAPY | G.D. SEARLE & CO. | 1997-12-09 | — | — | US | disclosed |