Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8626905 | 0.84 | ALDH1A1 (0.43) | SIGMAR1ALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL8919469 | 0.83 | MAPK1 (0.36) | SIGMAR1ALDH1A1HPGDMAPK1LMNA | |
| SCHEMBL8629045 | 0.80 | ALDH1A1 (0.41) | SIGMAR1ALDH1A1MAPK1 | |
| SCHEMBL8919157 | 0.79 | ALDH1A1 (0.35) | SIGMAR1ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL8626022 | 0.79 | ALDH1A1 (0.63) | SIGMAR1ALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL19023154 | 0.75 | HPGD (0.37) | ALDH1A1HPGDKDM4EL3MBTL1LMNA | |
| SCHEMBL8919693 | 0.75 | POLB (0.46) | ALDH1A1KDM4E | |
| SCHEMBL10392904 | 0.74 | ALDH1A1 (0.63) | SIGMAR1ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL46341 | 0.73 | ALDH1A1 (0.35) | ALDH1A1HPGDL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL8920278 | 0.73 | MEN1 (0.51) | SIGMAR1ALDH1A1MAPK1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |