Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8626905 | 0.82 | ALDH1A1 (0.43) | ALDH1A1HPGDSIGMAR1SMN1; SMN2HTT | |
| SCHEMBL8917897 | 0.79 | SIGMAR1 (0.42) | ALDH1A1HPGDSIGMAR1SMN1; SMN2KDM4E | |
| SCHEMBL8625701 | 0.78 | ALDH1A1 (0.40) | ALDH1A1HPGDSIGMAR1MEN1KMT2A | |
| SCHEMBL8700563 | 0.77 | ALDH1A1 (1.00) | ALDH1A1HPGDSIGMAR1SMN1; SMN2GLA | |
| SCHEMBL8919271 | 0.76 | ALDH1A1 (0.53) | ALDH1A1HPGDKMT2AKDM4EL3MBTL1 | |
| SCHEMBL8919693 | 0.76 | POLB (0.46) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8921700 | 0.76 | ALDH1A1 (0.42) | ALDH1A1HPGDSMN1; SMN2HTTMEN1 | |
| SCHEMBL8625812 | 0.75 | SIGMAR1 (0.42) | ALDH1A1HPGDSIGMAR1L3MBTL1LMNA | |
| SCHEMBL14565098 | 0.74 | ALDH1A1 (0.79) | ALDH1A1HPGDSIGMAR1SMN1; SMN2GLA | |
| SCHEMBL19023154 | 0.74 | HPGD (0.37) | ALDH1A1HPGDGLAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | claimed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | claimed |
| US-5767128-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1998-06-16 | — | — | US | disclosed |
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |