Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918109 | 0.90 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4EHTR1A | |
| SCHEMBL8919271 | 0.88 | ALDH1A1 (0.53) | POLBAPPALDH1A1MAPTKMT2A | |
| SCHEMBL8920278 | 0.87 | MEN1 (0.51) | POLBALDH1A1MEN1KMT2AHTR1A | |
| SCHEMBL8919198 | 0.87 | POLB (0.47) | POLBALDH1A1MAPTKDM4EHTR1A | |
| SCHEMBL8921274 | 0.85 | ALDH1A1 (0.45) | POLBAPPALDH1A1MAPTMEN1 | |
| SCHEMBL8629045 | 0.85 | ALDH1A1 (0.41) | POLBAPPALDH1A1MAPTMEN1 | |
| SCHEMBL8919157 | 0.82 | ALDH1A1 (0.35) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8918497 | 0.81 | DRD4 (0.53) | ALDH1A1MEN1KMT2AHTR1AHTR7 | |
| SCHEMBL8918424 | 0.80 | HTR1A (0.51) | MAPTHTR1AHTR7 | |
| SCHEMBL8920270 | 0.79 | KMT2A (0.52) | ALDH1A1MAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | claimed |
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |