Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | USP14 | P54578 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629045 | 0.87 | ALDH1A1 (0.41) | ALDH1A1HTTSIGMAR1MAPTMEN1 | |
| SCHEMBL8919271 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4EMAPTKMT2A | |
| SCHEMBL8919693 | 0.82 | POLB (0.46) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL8920278 | 0.79 | MEN1 (0.51) | ALDH1A1LMNASIGMAR1NPC1MEN1 | |
| SCHEMBL8917897 | 0.79 | SIGMAR1 (0.42) | ALDH1A1HPGDLMNASIGMAR1KDM4E | |
| SCHEMBL8625701 | 0.78 | ALDH1A1 (0.40) | ALDH1A1HPGDSIGMAR1KDM4EMEN1 | |
| SCHEMBL8919198 | 0.76 | POLB (0.47) | ALDH1A1LMNAKDM4EMAPTGAA | |
| SCHEMBL8626905 | 0.75 | ALDH1A1 (0.43) | ALDH1A1HTTHPGDLMNASIGMAR1 | |
| SCHEMBL8919469 | 0.72 | MAPK1 (0.36) | ALDH1A1HPGDLMNASIGMAR1 | |
| SCHEMBL8921274 | 0.67 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |