Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917897 | 0.83 | SIGMAR1 (0.42) | MAPK1ALDH1A1HPGDSIGMAR1LMNA | |
| SCHEMBL8625701 | 0.82 | ALDH1A1 (0.40) | HSD17B10ALDH1A1HPGDSIGMAR1 | |
| SCHEMBL8626905 | 0.76 | ALDH1A1 (0.43) | HSD17B10ALDH1A1HPGDSIGMAR1TDP1 | |
| SCHEMBL8626022 | 0.72 | ALDH1A1 (0.63) | MAPK1HSD17B10ALDH1A1HPGDSIGMAR1 | |
| SCHEMBL19023154 | 0.69 | HPGD (0.37) | HSD17B10ALDH1A1HPGDTSHRTDP1 | |
| SCHEMBL8919693 | 0.68 | POLB (0.46) | ALDH1A1 | |
| SCHEMBL8919271 | 0.68 | ALDH1A1 (0.53) | MAPK1ALDH1A1HPGDTSHRTP53 | |
| SCHEMBL7326070 | 0.68 | ALDH1A1 (0.35) | ALDH1A1HPGDTSHRLMNA | |
| SCHEMBL46341 | 0.67 | ALDH1A1 (0.35) | HSD17B10ALDH1A1HPGDTSHRTDP1 | |
| SCHEMBL8920278 | 0.66 | MEN1 (0.51) | MAPK1HSD17B10ALDH1A1SIGMAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |