Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.38 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920573 | 0.86 | RAB9A (0.49) | HTTTAAR1TP53KDM4EPOLB | |
| SCHEMBL8920367 | 0.84 | ALDH1A1 (0.49) | HTTROCK2ROCK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20986637 | 0.76 | KCNN4 (0.39) | SMN1; SMN2HSD17B10ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL8285639 | 0.73 | MAPT (0.42) | HTTPOLBHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL31620694 | 0.70 | KIF11 (0.42) | HTTJAK2TYK2TAAR1PLOD2 | |
| SCHEMBL8695362 | 0.69 | KIF11 (0.46) | HTTJAK2TYK2TAAR1ROCK2 | |
| SCHEMBL8226385 | 0.68 | KCNN4 (0.50) | TAAR1POLBHSD17B10NAPRTALDH1A1 | |
| SCHEMBL3322720 | 0.68 | MAPT (0.50) | TAAR1POLBHSD17B10NAPRTALDH1A1 | |
| SCHEMBL31358110 | 0.68 | KCNN4 (0.47) | TAAR1POLBHSD17B10NAPRTALDH1A1 | |
| SCHEMBL11298115 | 0.68 | AKR1C3 (0.42) | HTTJAK2TYK2TAAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0727998-A4 | OXAZOLES FOR TREATING CYTOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORP (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0727998-A1 | OXAZOLES FOR TREATING CYTOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013067-A1 | OXAZOLES FOR TREATING CYTOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-18 | — | — | WO | disclosed |