Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 2/20 | 0.31 |
| ▸ | LOX | P28300 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2093987 | 0.82 | SLC6A2 (0.38) | MEN1KMT2APPARAPPARGSLC6A2 | |
| Fluoride SCHEMBL27661482 | 0.80 | SLC6A2 (0.37) | MEN1KMT2APPARAPPARGSLC6A2 | |
| SCHEMBL19721617 | 0.77 | ALDH1A1 (0.38) | MEN1KMT2APPARGSLC6A2SLC6A4 | |
| SCHEMBL19721653 | 0.77 | ALDH1A1 (0.38) | MEN1KMT2APPARGSLC6A2SLC6A4 | |
| Tromethamine SCHEMBL5702541 | 0.75 | LMNA (0.43) | MEN1LMNAKMT2A | |
| SCHEMBL27955698 | 0.75 | SLC6A2 (0.38) | TRPV1SLC6A2SLC6A4SLC6A3ACACB | |
| Alcohol SCHEMBL28244815 | 0.74 | PPARA (0.44) | MEN1LMNAKMT2APPARAPPARG | |
| Biphenyl SCHEMBL27873955 | 0.72 | KIF11 (0.39) | MEN1LMNAKMT2APPARAPPARG | |
| SCHEMBL17929065 | 0.71 | TSHR (0.33) | PPARAPPARG | |
| SCHEMBL26746 | 0.71 | SLC6A2 (0.44) | MEN1KMT2APPARAPPARGSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624787-A | NITROGENOUS COMPOUND AND SULFONIUM COMPOUND FOR POSITIVE PHOTORESISTS | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1997-04-29 | — | — | US | claimed |