Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mequinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Hydroxy-4-Ethoxybenzene SCHEMBL10587102 | 0.88 | LTA4H (0.46) | LTA4HMCL1CYP1A2 | |
| Mequinol SCHEMBL8923068 | 0.85 | MCL1 (0.58) | LTA4HESR2MCL1CALM1APP | |
| SCHEMBL22129831 | 0.84 | SIGMAR1 (0.40) | MCL1HTR2ACYP1A2CYP2A6 | |
| Anthracene SCHEMBL8925919 | 0.77 | ESR2 (0.64) | LTA4HESR2ESR1CALM1APP | |
| Mequinol SCHEMBL8924974 | 0.77 | CYP1A2 (0.49) | LTA4HESR2CALM1APPTUBB4A | |
| SCHEMBL15478214 | 0.77 | CYP1A2 (0.43) | HTR2ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL11817172 | 0.76 | ALDH1A1 (0.49) | ESR2MCL1ESR1CYP1A2 | |
| Mequinol SCHEMBL10589275 | 0.76 | LTA4H (0.46) | LTA4HESR2CALM1APPTUBB4A | |
| SCHEMBL10053553 | 0.74 | TOP2A (0.38) | LTA4HTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1408683 | 0.72 | CYP1A2 (0.44) | AKR1B1HTR2ACRHR1CYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663032-A | NAPHTHOL DERIVATIVE REDUCING AGENT | CANON KABUSHIKI KAISHA (JP) | 1997-09-02 | — | — | US | disclosed |
| EP-0653680-A2 | Photosensitive composition, photosensitive material and image forming method | CANON KABUSHIKI KAISHA (JP) | 1995-05-17 | — | — | EP | disclosed |
| EP-0326424-A2 | Photosensitive composition, photosensitive material, and image forming method | CANON KABUSHIKI KAISHA (JP) | 1989-08-02 | — | — | EP | disclosed |