Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924472 | 0.90 | L3MBTL1 (0.33) | CHRM2CHRM1CHRM3ALDH1A1 | |
| SCHEMBL8923583 | 0.90 | L3MBTL1 (0.32) | ALDH1A1 | |
| SCHEMBL9362959 | 0.89 | MTNR1A (0.34) | OPRM1MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL8924342 | 0.87 | ALDH1A1 (0.35) | OPRM1MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL8921163 | 0.85 | CCKBR (0.38) | OPRM1MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL9362054 | 0.85 | ALDH1A1 (0.45) | OPRM1MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL8922568 | 0.81 | MAPT (0.32) | OPRM1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8922114 | 0.80 | MDM2 (0.32) | OPRM1 | |
| SCHEMBL8920916 | 0.79 | GRIN2B (0.35) | OPRM1MTNR1AMTNR1BGHSRKMT2A | |
| SCHEMBL9365841 | 0.78 | NPSR1 (0.32) | SMN1; SMN2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |