Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924472 | 0.91 | L3MBTL1 (0.33) | L3MBTL1ALDH1A1CCR1CCR2 | |
| SCHEMBL8922114 | 0.90 | MDM2 (0.32) | HSD11B1TP53MDM2 | |
| SCHEMBL8922635 | 0.90 | OPRM1 (0.33) | ALDH1A1 | |
| SCHEMBL9362140 | 0.88 | L3MBTL1 (0.33) | L3MBTL1ALDH1A1CCR1CCR2HSD11B1 | |
| SCHEMBL8919291 | 0.87 | CCKBR (0.32) | L3MBTL1ALDH1A1CCR1CCR2HSD11B1 | |
| SCHEMBL8922628 | 0.85 | PLA2G10 (0.35) | L3MBTL1ALDH1A1CCR1CCR2TP53 | |
| SCHEMBL9362772 | 0.84 | HSD11B1 (0.36) | L3MBTL1ALDH1A1HSD11B1 | |
| SCHEMBL8922568 | 0.81 | MAPT (0.32) | L3MBTL1ALDH1A1HSD11B1TP53 | |
| SCHEMBL9365841 | 0.78 | NPSR1 (0.32) | L3MBTL1ALDH1A1CCR1CCR2 | |
| SCHEMBL8920231 | 0.78 | CCKBR (0.31) | TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |