Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.32 |
| ▸ | TP53 | P04637 | 4/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922568 | 0.92 | MAPT (0.32) | TP53HSD11B1OPRM1OPRD1UTS2R | |
| SCHEMBL8923583 | 0.90 | L3MBTL1 (0.32) | MDM2TP53HSD11B1 | |
| SCHEMBL8920231 | 0.88 | CCKBR (0.31) | MDM2TP53GRIN2B | |
| SCHEMBL8924472 | 0.81 | L3MBTL1 (0.33) | — | |
| SCHEMBL8922635 | 0.80 | OPRM1 (0.33) | OPRM1 | |
| SCHEMBL8920916 | 0.80 | GRIN2B (0.35) | GRIN2BOPRM1OPRD1UTS2R | |
| SCHEMBL8926039 | 0.79 | DRD2 (0.32) | TP53 | |
| SCHEMBL8922117 | 0.79 | CCKBR (0.48) | GRIN2B | |
| SCHEMBL8920820 | 0.79 | CCKBR (0.40) | TP53 | |
| SCHEMBL9362140 | 0.79 | L3MBTL1 (0.33) | MDM2TP53HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |