Indoline

Indoline

SCHEMBL8922922

COCC(=O)O.c1ccc2c(c1)CCN2

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.38
POLB P06746 1/20 0.38
CD69 Q07108 1/20 0.38
ALDH1A1 P00352 3/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
CYP1A2 P05177 1/20 0.38
BRD4 O60885 1/20 0.38
DRD2 P14416 1/20 0.37
DRD4 P21917 1/20 0.37
PDPK1 O15530 1/20 0.37
PARP1 P09874 1/20 0.37
PARP10 Q53GL7 1/20 0.37
PARP11 Q9NR21 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
MTNR1A P48039 1/20 0.36
MTNR1B P49286 1/20 0.36
ALOX15 P16050 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indoline SCHEMBL8918364 0.82 ALDH1A1 (0.49) MAPK1POLBALDH1A1MEN1KMT2A
Indoline SCHEMBL17652456 0.82 DRD2 (0.44) MAPK1ALDH1A1MEN1KMT2ACYP1A2
Indoline SCHEMBL9093000 0.81 NOTUM (0.45) MAPK1SMN1; SMN2ALDH1A1MEN1KMT2A
Indoline SCHEMBL27915873 0.81 MEN1 (0.44) MAPK1SMN1; SMN2MEN1KMT2ABRD4
Indoline SCHEMBL28278331 0.81 MEN1 (0.44) MAPK1SMN1; SMN2MEN1KMT2ABRD4
Indoline SCHEMBL28301724 0.80 ALDH1A1 (0.45) MAPK1SMN1; SMN2POLBALDH1A1MEN1
Indoline SCHEMBL5069264 0.79 PARP10 (0.44) MAPK1ALDH1A1MEN1KMT2ACYP1A2
Phenylacetic Acid SCHEMBL27898390 0.78 AKR1B1 (0.55) ALDH1A1CYP1A2DRD2DRD4PARP11
Indoline SCHEMBL3905169 0.78 HTR2C (0.50) SMN1; SMN2ALDH1A1MEN1KMT2ADRD2
Indoline SCHEMBL28003951 0.78 MTNR1A (0.43) MAPK1SMN1; SMN2ALDH1A1BRD4DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5691272-A Carboxylate and heat-sensitive recording material using same MITSUI TOATSU CHEMICALS, INC. (JP) 1997-11-25 US disclosed
US-5559247-A Carboxylate and heat-sensitive recording material using same MITSUI TOATSU CHEMICALS, INC. (JP) 1996-09-24 US disclosed