Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PRKDC | P78527 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922352 | 0.89 | ALDH1A1 (0.41) | PIK3CASMN1; SMN2PIK3CDPIK3CGMTOR | |
| SCHEMBL8922256 | 0.88 | HSD17B10 (0.49) | PIK3CAPRKDCSMN1; SMN2MAPTPIK3CD | |
| SCHEMBL8920356 | 0.88 | AKR1C3 (0.40) | PRKDCSMN1; SMN2MAPTAKR1C3PHGDH | |
| SCHEMBL8922826 | 0.80 | ALDH1A1 (0.43) | PIK3CAPRKDCPIK3CDPIK3CGMTOR | |
| SCHEMBL8921644 | 0.73 | ALDH1A1 (0.57) | PIK3CAPRKDCSMN1; SMN2MAPTPIK3CD | |
| SCHEMBL8923374 | 0.72 | ALDH1A1 (0.40) | PRKDCSMN1; SMN2MAPTAKR1C3PHGDH | |
| SCHEMBL8922784 | 0.72 | HSD17B10 (0.45) | PIK3CASMN1; SMN2MAPTPIK3CDPIK3CG | |
| SCHEMBL9857290 | 0.71 | POLB (0.43) | PIK3CASMN1; SMN2MAPTPIK3CGMTOR | |
| SCHEMBL6408282 | 0.70 | NPC1 (0.39) | SMN1; SMN2MAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL8923331 | 0.70 | HPGD (0.56) | PIK3CAPRKDCSMN1; SMN2MAPTPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684160-A | 3-aminopyrroles, methods for their synthesis and for their pharmaceutical use | ARZNEIMETTELWERK DRESDEN GMBH (DE) | 1997-11-04 | — | — | US | claimed |
| US-5502051-A | CENTRAL NERVOUS SYSTEM, ANTISPASMODIC | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1996-03-26 | — | — | US | claimed |
| US-5684160-A | 3-aminopyrroles, methods for their synthesis and for their pharmaceutical use | ARZNEIMETTELWERK DRESDEN GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5502051-A | CENTRAL NERVOUS SYSTEM, ANTISPASMODIC | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1996-03-26 | — | — | US | disclosed |