Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922256 | 0.90 | HSD17B10 (0.49) | ALDH1A1HPGDUSP2CHRNA7CYP2D6 | |
| SCHEMBL8920356 | 0.89 | AKR1C3 (0.40) | ALDH1A1HPGDAKR1C3HSD17B10ALOX15 | |
| SCHEMBL8923602 | 0.89 | PIK3CA (0.42) | ALDH1A1AKR1C3PIK3CAPIK3CGMTOR | |
| SCHEMBL9857290 | 0.81 | POLB (0.43) | ALDH1A1HPGDUSP2FKBP1ACHRNA7 | |
| SCHEMBL8923375 | 0.74 | ALDH1A1 (0.63) | ALDH1A1HPGDUSP2FKBP1ACHRNA7 | |
| SCHEMBL8923374 | 0.73 | ALDH1A1 (0.40) | ALDH1A1HPGDAKR1C3HSD17B10ALOX15 | |
| SCHEMBL9857777 | 0.71 | ALDH1A1 (0.47) | ALDH1A1HPGDUSP2CHRNA7HSD17B10 | |
| SCHEMBL8925211 | 0.70 | ALDH1A1 (0.54) | ALDH1A1HPGDHSD17B10ALOX15KDM4E | |
| SCHEMBL8922784 | 0.70 | HSD17B10 (0.45) | ALDH1A1HPGDFKBP1AHSD17B10ALOX15 | |
| SCHEMBL8922826 | 0.69 | ALDH1A1 (0.43) | ALDH1A1HPGDAKR1C3HSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684160-A | 3-aminopyrroles, methods for their synthesis and for their pharmaceutical use | ARZNEIMETTELWERK DRESDEN GMBH (DE) | 1997-11-04 | — | — | US | claimed |
| US-5502051-A | CENTRAL NERVOUS SYSTEM, ANTISPASMODIC | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1996-03-26 | — | — | US | claimed |
| EP-0431371-A1 | 3-Aminopyrroles, process for this preparation and their use as medicaments | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-06-12 | — | — | EP | claimed |
| US-5684160-A | 3-aminopyrroles, methods for their synthesis and for their pharmaceutical use | ARZNEIMETTELWERK DRESDEN GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5502051-A | CENTRAL NERVOUS SYSTEM, ANTISPASMODIC | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1996-03-26 | — | — | US | disclosed |