SCHEMBL8924613

SCHEMBL8924613

CCOc1c(C)c(C)c(OCc2ccccc2)c(CNCCOc2cc(C)ccc2C(C)C)c1C

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 5/20 0.46
ADRA1D P25100 4/20 0.46
ADRA1A P35348 4/20 0.46
ADRA1B P35368 4/20 0.46
KMT2A Q03164 5/20 0.43
MEN1 O00255 4/20 0.43
ALDH1A1 P00352 3/20 0.43
MAPT P10636 1/20 0.43
MAPK1 P28482 1/20 0.43
ATM Q13315 1/20 0.43
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
HTT P42858 2/20 0.40
KDM4E B2RXH2 1/20 0.40
GAA P10253 1/20 0.40
ALOX12 P18054 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
NPBWR1 P48145 1/20 0.39
MCHR1 Q99705 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8924466 0.83 MEN1 (0.47) KMT2AMEN1ALDH1A1MAPTATM
SCHEMBL8923441 0.74 KMT2A (0.56) ADRA1DADRA1AADRA1BKMT2AMEN1
SCHEMBL30298322 0.72 MEN1 (0.54) KMT2AMEN1ALDH1A1MAPTATM
SCHEMBL8923685 0.67 MEN1 (0.56) KMT2AMEN1ALDH1A1MAPTATM
SCHEMBL8924282 0.67 ADRA1D (0.58) ADRA1DADRA1AADRA1BKMT2AMEN1
SCHEMBL8960589 0.67 ALDH1A1 (0.55) KMT2AMEN1ALDH1A1MAPTMAPK1
SCHEMBL8246277 0.67 ALDH1A1 (0.55) ADRA1AKMT2AMEN1ALDH1A1MAPT
SCHEMBL9678575 0.66 L3MBTL4 (0.57) KMT2AMEN1ALDH1A1MAPTATM
SCHEMBL15086403 0.66 ALDH1A1 (0.62) KMT2AMEN1ALDH1A1MAPTMAPK1
Hydrochloric Acid SCHEMBL9471893 0.65 L3MBTL4 (0.56) KMT2AMEN1ALDH1A1MAPTATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5624961-A Benzylaminoethoxybenzene derivatives, production thereof and use thereof JAPAN TOBACCO INC. (JP) 1997-04-29 US disclosed
EP-0693474-A1 NOVEL BENZYLAMINOETHOXYBENZENE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Toyo Boseki Kabushiki Kaisha (JP) 1996-01-24 EP disclosed