Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963230 | 0.69 | PLA2G2A (0.86) | PLA2G2APLA2G1BPKMMEN1KMT2A | |
| SCHEMBL6036137 | 0.68 | HSD17B10 (0.68) | L3MBTL1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL14478865 | 0.68 | RAB9A (0.61) | L3MBTL1NPC1RAB9APKMSMN1; SMN2 | |
| SCHEMBL503725 | 0.68 | MAPT (0.48) | L3MBTL1NPC1RAB9APKMSMN1; SMN2 | |
| SCHEMBL5645826 | 0.68 | LMNA (0.80) | PTGDR2PLA2G2ARAB9AMEN1KMT2A | |
| SCHEMBL6034660 | 0.67 | RXRA (0.56) | L3MBTL1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL3386778 | 0.66 | KDM4E (0.73) | NPC1RAB9APKMSMN1; SMN2MEN1 | |
| SCHEMBL12255371 | 0.66 | MEN1 (0.43) | PTGDR2PLA2G2APLA2G1BSMN1; SMN2MEN1 | |
| SCHEMBL1097150 | 0.66 | L3MBTL1 (0.61) | L3MBTL1MAOB | |
| SCHEMBL14404895 | 0.65 | AKR1C3 (0.59) | PTGDR2PLA2G2APLA2G1BRAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |