Sugi Predict

Sugi Predict / Compounds / SCHEMBL892709

SCHEMBL892709

SCHEMBL892709

NCCc1c[nH]c2ccc(C(F)(F)F)cc12

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR1D P28221 10/20 0.73
▸ HTR2A P28223 8/20 0.65
▸ TRPM8 Q7Z2W7 4/20 0.65
▸ MPO P05164 3/20 0.65
▸ HTR1A P08908 8/20 0.63
▸ KMT2A Q03164 2/20 0.63
▸ HTR1B P28222 7/20 0.60
▸ HTR2C P28335 5/20 0.60
▸ HTR7 P34969 5/20 0.60
▸ CYP1A2 P05177 4/20 0.60
▸ HTR6 P50406 4/20 0.60
▸ TSHR P16473 3/20 0.60
▸ HTR2B P41595 2/20 0.60
▸ HTR4 Q13639 2/20 0.60
▸ HTR5A P47898 2/20 0.60
▸ CYP3A4 P08684 2/20 0.60
▸ CYP2D6 P10635 2/20 0.60
▸ TAAR1 Q96RJ0 2/20 0.60
▸ HTR3E A5X5Y0 1/20 0.60
▸ HTR3B O95264 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL21546043 0.98 HTR1D (0.71) HTR1DHTR2ATRPM8MPOHTR1A
SCHEMBL7326143 0.88 HTR1D (0.62) HTR1DHTR2ATRPM8MPOHTR1A
SCHEMBL2537034 0.88 HTR2A (0.65) HTR1DHTR2ATRPM8MPOHTR1A
SCHEMBL30532276 0.84 HTR1D (0.52) HTR1DHTR2ATRPM8MPOHTR1A
SCHEMBL17375886 0.84 HTR1D (0.52) HTR1DHTR2ATRPM8MPOHTR1A
SCHEMBL11540599 0.84 HTR2C (0.62) HTR1DMPOHTR1AKMT2AHTR1B
SCHEMBL7853204 0.84 HTR1D (1.00) HTR1DHTR2ATRPM8MPOHTR1A
Hydrochloric Acid SCHEMBL7306921 0.84 MAOB (0.58) HTR1DHTR2ATRPM8MPOHTR1A
Hydrochloric Acid SCHEMBL7680692 0.83 HTR1D (0.97) HTR1DHTR2ATRPM8MPOHTR1A
SCHEMBL8868820 0.82 TRPM8 (0.71) HTR1DHTR2ATRPM8MPOHTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4406957-B1 ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME NOGRA PHARMA LTD (IE) 2026-04-08 — — EP disclosed
US-12577256-B2 Aryl receptor modulators and methods of making and using the same NOGRA PHARMA LIMITED (IE) 2026-03-17 — — US disclosed
US-20250074873-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-03-06 — — US disclosed
US-20250066384-A1 ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME NOGRA PHARMA LIMITED (IE) 2025-02-27 — — US disclosed
EP-4452938-A1 COMPOUNDS Psylo Pty Ltd (AU) 2024-10-30 — — EP disclosed
CN-118696029-A Compounds of formula (I) 普赛洛私人有限公司 2024-09-24 — — CN disclosed
EP-4406957-A2 ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME Nogra Pharma Limited (IE) 2024-07-31 — — EP disclosed
US-12012418-B2 Aryl receptor modulators and methods of making and using the same NOGRA PHARMA LIMITED (IE) 2024-06-18 — — US disclosed
EP-3160964-B1 ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME NOGRA PHARMA LTD (IE) 2024-03-13 — — EP disclosed
CN-116947880-A Aryl receptor modulators and methods of making and using the same 诺格拉制药有限公司 2023-10-27 — — CN disclosed
US-20070099909-A1 N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR CHEN ZHAOGEN 2007-05-03 — — US disclosed
US-20070004765-A1 New compounds BIOVITRUM AB (SE) 2007-01-04 — — US disclosed
US-7157488-B2 N-(2-Arylethyl) benzylamines as antagonists of the 5-HT6 receptor ELI LILLY AND COMPANY (US) 2007-01-02 — — US disclosed
WO-2006122931-A1 BETA-CARBOLINE DERIVATIVES AND THERI USE AS GHSR MODULATORS BIOVITRUM AB (PUBL) (SE) 2006-11-23 — — WO disclosed
US-20060009511-A9 N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor CHEN ZHAOGEN 2006-01-12 — — US disclosed
CN-1610547-A N-(2-arylethyl)benzylamines as antagonists of the 5-HT6 receptor LILLY CO ELI (US) 2005-04-27 — — CN disclosed
EP-1379239-A2 N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2004-01-14 — — EP disclosed
WO-2002078693-A2 N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2002-10-10 — — WO disclosed
US-6350757-B1 Beta-carboline compounds LES LABORATOIRES SERVIER (FR) 2002-02-26 — — US disclosed
EP-1070716-A1 Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 2001-01-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12577256-B2 Aryl receptor modulators and methods of making and using the same AHR, IL23R, ARNT HTR1D 942/4885HTR2A 202/4885TRPM8 476/4885
US-20250066384-A1 ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME AHR, IFNAR1, IL23R HTR1D 949/4885HTR2A 211/4885TRPM8 1745/4885
US-20070004765-A1 New compounds GHSR, GIPR, PRLHR HTR1D 612/4885HTR2A 854/4885TRPM8 4145/4885
US-12012418-B2 Aryl receptor modulators and methods of making and using the same AHR, IL23R, IL2RA HTR1D 722/4885HTR2A 127/4885TRPM8 2087/4885
US-20060009511-A9 N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor HTR6, HTR2C, HTR1B HTR1D 16/4885HTR2A 5/4885TRPM8 511/4885
US-20250074873-A1 COMPOUNDS NLN, SLC18A2, PYGB HTR1D 344/4885HTR2A 94/4885TRPM8 1051/4885
US-20070099909-A1 N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR HTR6, HTR2C, HTR1B HTR1D 16/4885HTR2A 5/4885TRPM8 511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.