Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | OGG1 | O15527 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8608573 | 0.87 | LMNA (0.33) | SMN1; SMN2NPC1CYP1A2CYP2C9HPGD | |
| SCHEMBL5051468 | 0.85 | SMN1; SMN2 (0.33) | SMN1; SMN2NPC1CYP1A2CYP2C9HPGD | |
| SCHEMBL317948 | 0.76 | RAB9A (0.52) | SMN1; SMN2NPC1CYP1A2CYP2C9HPGD | |
| SCHEMBL4327858 | 0.75 | HDAC1 (0.35) | SMN1; SMN2CYP4F2CYP4A11 | |
| SCHEMBL2356948 | 0.74 | PRSS1 (0.42) | CYP2C19RAB9A | |
| SCHEMBL30185957 | 0.73 | KMT2A (0.46) | SMN1; SMN2 | |
| SCHEMBL1884032 | 0.73 | KMT2A (0.46) | SMN1; SMN2 | |
| SCHEMBL2392823 | 0.73 | HPGD (0.47) | SMN1; SMN2HPGDRAB9AOGG1 | |
| SCHEMBL8979725 | 0.72 | PARP1 (0.46) | SMN1; SMN2NPC1 | |
| SCHEMBL11149238 | 0.71 | CES2 (0.51) | CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5601801-A | A MODIFIED LYSYL-L-PROLINE LABELLED WITH AN ISOTOPE OF IODINE; USEFUL IN IMAGING KIDNEYS AND LUNGS FOR DIAGNOSIS AND TREATMENT OF DISEASES | MERCK FROSST CANADA, INC. (CA) | 1997-02-11 | — | — | US | disclosed |