SCHEMBL8932190

SCHEMBL8932190

CCOC(=O)[C@H](Cc1cc(O)c(O)cc1I)NC=O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.35
CA12 O43570 3/20 0.33
CA1 P00915 3/20 0.33
CA2 P00918 3/20 0.33
CA7 P43166 3/20 0.33
CA9 Q16790 3/20 0.33
CA14 Q9ULX7 3/20 0.33
ALOX15 P16050 1/20 0.33
ALOX12 P18054 1/20 0.33
CYP3A4 P08684 3/20 0.33
LMNA P02545 2/20 0.33
ALDH1A1 P00352 2/20 0.33
CYP1A2 P05177 2/20 0.33
TSHR P16473 2/20 0.33
BACE1 P56817 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
TTR P02766 1/20 0.33
DPP4 P27487 1/20 0.33
MAPT P10636 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8932192 0.85 CA1 (0.39) CA12CA1CA2CA9CYP3A4
SCHEMBL5664158 0.78 MTNR1A (0.38) ALOX12ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL29421743 0.71 APLNR (0.47) ALDH1A1TSHRMAPTMEN1MAPK1
SCHEMBL7882117 0.71 MMP8 (0.55) EGFRALDH1A1TP53MEN1KMT2A
SCHEMBL6952367 0.71 MMP8 (0.55) EGFRALDH1A1TP53MEN1KMT2A
SCHEMBL15694356 0.69 MEN1 (0.46) ALOX15ALOX12CYP3A4LMNAALDH1A1
SCHEMBL7385062 0.69 MTNR1A (0.51) LMNAALDH1A1MAPTTP53THRB
SCHEMBL7385065 0.69 MTNR1A (0.51) LMNAALDH1A1MAPTTP53THRB
SCHEMBL4538023 0.69 HDAC1 (0.45) LMNAALDH1A1BACE1MAPTTP53
SCHEMBL4538019 0.69 HDAC1 (0.45) LMNAALDH1A1BACE1MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5393908-A Storage stable intermediate NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 1995-02-28 US claimed
WO-1994000460-A9 SYNTHESIS OF N-FORMYL-3,4-DI-t-BUTOXYCARBONYLOXY-6-(TRIMETHYLSTANNYL)-L-PHENYLALANINE ETHYL ESTER AND ITS REGIOSELECTIVE RADIOFLUORODESTANNYLATION TO 6-[18F]FLUORO-L-DOPA 1994-02-17 WO claimed
WO-1994000460-A1 SYNTHESIS OF N-FORMYL-3,4-DI-t-BUTOXYCARBONYLOXY-6-(TRIMETHYLSTANNYL)-L-PHENYLALANINE ETHYL ESTER AND ITS REGIOSELECTIVE RADIOFLUORODESTANNYLATION TO 6-[18F]FLUORO-L-DOPA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1994-01-06 WO claimed
US-5510522-A AMIDATION, IODINATION, METALLIZATION, RADIOFLUORINATION OF DOPA AND DERIVATIVES THEREOF; SHELF STABLE PRECURSOR, HIGH YIELDS REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-04-23 US disclosed
US-5393908-A Storage stable intermediate NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 1995-02-28 US disclosed
WO-1994000460-A9 SYNTHESIS OF N-FORMYL-3,4-DI-t-BUTOXYCARBONYLOXY-6-(TRIMETHYLSTANNYL)-L-PHENYLALANINE ETHYL ESTER AND ITS REGIOSELECTIVE RADIOFLUORODESTANNYLATION TO 6-[18F]FLUORO-L-DOPA 1994-02-17 WO disclosed
WO-1994000460-A1 SYNTHESIS OF N-FORMYL-3,4-DI-t-BUTOXYCARBONYLOXY-6-(TRIMETHYLSTANNYL)-L-PHENYLALANINE ETHYL ESTER AND ITS REGIOSELECTIVE RADIOFLUORODESTANNYLATION TO 6-[18F]FLUORO-L-DOPA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1994-01-06 WO disclosed