Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 3/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538023 | 1.00 | HDAC1 (0.45) | HDAC1HDAC6MMP8MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL30068344 | 0.87 | HDAC1 (0.55) | HDAC1HDAC6KMT2AMEN1ALDH1A1 | |
| SCHEMBL6952367 | 0.85 | MMP8 (0.55) | MMP8KMT2AMEN1HPRT1ALDH1A1 | |
| SCHEMBL7882117 | 0.85 | MMP8 (0.55) | MMP8KMT2AMEN1HPRT1ALDH1A1 | |
| SCHEMBL27675105 | 0.84 | EPHX2 (0.50) | MAPTKMT2AMEN1LMNANPSR1 | |
| SCHEMBL28209573 | 0.81 | LMNA (0.46) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL5887222 | 0.81 | TACR1 (0.53) | HDAC1HDAC6MMP8MAPTLMNA | |
| SCHEMBL6435910 | 0.81 | TACR1 (0.53) | HDAC1HDAC6MMP8MAPTLMNA | |
| SCHEMBL5887220 | 0.81 | TACR1 (0.53) | HDAC1HDAC6MMP8MAPTLMNA | |
| SCHEMBL19706379 | 0.80 | FPR2 (0.51) | KMT2AMEN1MMEFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11542242-B2 | Substituted piperazines as selective HDAC1,2 inhibitors | REGENACY PHARMACEUTICALS, LLC (US) | 2023-01-03 | — | — | US | disclosed |
| US-20220281833-A1 | SUBSTITUTED PIPERAZINES AS SELECTIVE HDAC1,2 INHIBITORS | REGENACY PHARMACEUTICALS, LLC | 2022-09-08 | — | — | US | disclosed |
| US-20200377465-A1 | SUBSTITUTED PIPERAZINES AS SELECTIVE HDAC1,2 INHIBITORS | REGENACY PHARMACEUTICALS, LLC | 2020-12-03 | — | — | US | disclosed |
| US-10774056-B2 | Substituted piperazines as selective HDAC1,2 inhibitors | REGENACY PHARMACEUTICALS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190330169-A1 | SELECTIVE HDAC1,2 INHIBITORS | REGENACY PHARMACEUTICALS, LLC | 2019-10-31 | — | — | US | disclosed |
| EP-3544969-A1 | PIPERAZINE DERIVATIVES AS SELECTIVE HDAC1,2 INHIBITORS | Regenacy Pharmaceuticals, LLC (US) | 2019-10-02 | — | — | EP | disclosed |
| US-10385031-B2 | Substituted piperazines as selective HDAC1,2 inhibitors | REGENACY PHARMACEUTICALS, LLC (US) | 2019-08-20 | — | — | US | disclosed |
| EP-2951153-B1 | SELECTIVE HDAC3 INHIBITORS | REGENACY PHARMACEUTICALS LLC (US) | 2019-04-03 | — | — | EP | disclosed |
| US-10125131-B2 | Selective HDAC3 inhibitors | REGENACY PHARMACEUTICALS, LLC (US) | 2018-11-13 | — | — | US | disclosed |
| WO-2018098296-A1 | PIPERAZINE DERIVATIVES AS SELECTIVE HDAC1,2 INHIBITORS | REGENACY PHARMACEUTICALS, LLC (US) | 2018-05-31 | — | — | WO | disclosed |
| US-9096549-B2 | Selective HDAC3 inhibitors | ACETYLON PHARMACEUTICALS, INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-9096549-B2 | Selective HDAC3 inhibitors | ACETYLON PHARMACEUTICALS, INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-9096549-B2 | Selective HDAC3 inhibitors | ACETYLON PHARMACEUTICALS, INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140243345-A1 | SELECTIVE HDAC3 INHIBITORS | REGENACY PHARMACEUTICALS, LLC | 2014-08-28 | — | — | US | disclosed |
| US-20140243345-A1 | SELECTIVE HDAC3 INHIBITORS | REGENACY PHARMACEUTICALS, LLC | 2014-08-28 | — | — | US | disclosed |
| US-20140243345-A1 | SELECTIVE HDAC3 INHIBITORS | REGENACY PHARMACEUTICALS, LLC | 2014-08-28 | — | — | US | disclosed |
| WO-2014121062-A1 | SELECTIVE HDAC3 INHIBITORS | ACETYLON PHARMACEUTICALS, INC. (US) | 2014-08-07 | — | — | WO | disclosed |
| WO-2014121062-A1 | SELECTIVE HDAC3 INHIBITORS | ACETYLON PHARMACEUTICALS, INC. (US) | 2014-08-07 | — | — | WO | disclosed |
| US-20090264426-A1 | Bicyclic aromatic substituted pyridone derivative | MSD K.K. (JP) | 2009-10-22 | — | — | US | disclosed |
| EP-1939194-A1 | BICYCLIC AROMATIC SUBSTITUTED PYRIDONE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385031-B2 | Substituted piperazines as selective HDAC1,2 inhibitors | HDAC1, HDAC2, HDAC11 | HDAC1 1/4885HDAC6 5/4885MMP8 1011/4885 |
| US-20140243345-A1 | SELECTIVE HDAC3 INHIBITORS | HDAC3, HDAC1, HDAC11 | HDAC1 2/4885HDAC6 7/4885MMP8 2468/4885 |
| US-11542242-B2 | Substituted piperazines as selective HDAC1,2 inhibitors | HDAC1, HDAC2, HDAC11 | HDAC1 1/4885HDAC6 7/4885MMP8 1135/4885 |
| US-20220281833-A1 | SUBSTITUTED PIPERAZINES AS SELECTIVE HDAC1,2 INHIBITORS | HDAC1, HDAC2, HDAC11 | HDAC1 1/4885HDAC6 6/4885MMP8 1490/4885 |
| US-10774056-B2 | Substituted piperazines as selective HDAC1,2 inhibitors | HDAC1, HDAC2, HDAC11 | HDAC1 1/4885HDAC6 6/4885MMP8 1618/4885 |
| US-20200377465-A1 | SUBSTITUTED PIPERAZINES AS SELECTIVE HDAC1,2 INHIBITORS | HDAC1, HDAC2, HDAC11 | HDAC1 1/4885HDAC6 6/4885MMP8 1490/4885 |
| US-20190330169-A1 | SELECTIVE HDAC1,2 INHIBITORS | HDAC1, HDAC2, HDAC11 | HDAC1 1/4885HDAC6 5/4885MMP8 1137/4885 |
| US-10125131-B2 | Selective HDAC3 inhibitors | HDAC3, HDAC1, HDAC11 | HDAC1 2/4885HDAC6 7/4885MMP8 2468/4885 |
| US-20090264426-A1 | Bicyclic aromatic substituted pyridone derivative | PYCR1, CHRM1, MTR | HDAC1 964/4885HDAC6 4082/4885MMP8 4699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.