Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8708337 | 0.94 | L3MBTL1 (0.36) | NPC1TDP1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL32682741 | 0.78 | NPSR1 (0.48) | NPC1TDP1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL261104 | 0.78 | NPSR1 (0.48) | NPC1TDP1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL7857665 | 0.77 | KDM4E (0.33) | KDM4EALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL5773639 | 0.76 | NPSR1 (0.46) | NPC1TDP1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL71518 | 0.65 | NPSR1 (0.59) | TDP1KDM4ESMN1; SMN2ALDH1A1GAA | |
| SCHEMBL29133980 | 0.65 | L3MBTL1 (0.41) | KDM4ESMN1; SMN2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL13482134 | 0.64 | TMPRSS15 (0.41) | RAB9ASMN1; SMN2ALDH1A1L3MBTL1GBA1 | |
| SCHEMBL29642902 | 0.64 | RAB9A (0.55) | NPC1TDP1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL3979132 | 0.64 | RAB9A (0.55) | NPC1TDP1KDM4ERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022991-A1 | BICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |