Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5639914 | 0.84 | POLB (0.47) | POLBNR4A2KMT2AKDM4EMEN1 | |
| SCHEMBL2190816 | 0.81 | POLB (0.45) | POLBNR4A2L3MBTL1KMT2AKDM4E | |
| SCHEMBL9828612 | 0.79 | F2 (0.56) | POLBDHFRLMNAL3MBTL1KMT2A | |
| SCHEMBL8936165 | 0.79 | POLB (0.42) | POLBNR4A2LMNAKMT2AKDM4E | |
| SCHEMBL8936155 | 0.78 | POLB (0.72) | POLBNR4A2LMNAKMT2AKDM4E | |
| SCHEMBL6492060 | 0.78 | POLB (1.00) | POLBNR4A2LMNAKMT2AKDM4E | |
| SCHEMBL9828211 | 0.77 | LMNA (0.47) | POLBDHFRLMNAL3MBTL1KMT2A | |
| SCHEMBL423891 | 0.77 | L3MBTL1 (0.71) | POLBLMNAL3MBTL1KMT2AKDM4E | |
| SCHEMBL23619822 | 0.72 | CYP1A2 (0.51) | POLBDHFRLMNAL3MBTL1KMT2A | |
| SCHEMBL23619823 | 0.72 | CYP1A2 (0.51) | POLBDHFRLMNAL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510338-A | ADMINISTERING TO A MAMMAL TO RELIEVE PAIN AND TO TREAT CONVULSIONS, CEREBRAL ISCHEMIC DAMAGE, AND EMESIS | GUILFORD PHARMACEUTICALS INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5342946-A | Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors | GUILFORD PHARMACEUTICALS INC. (US) | 1994-08-30 | — | — | US | disclosed |