SCHEMBL8938495

SCHEMBL8938495

OCCc1ccccc1C1COCCO1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR5A P47898 1/20 0.32
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3771929 0.87 HTR5A (0.33) HTR5ATDP1
SCHEMBL9692553 0.84 TAAR1 (0.38) HTR5A
SCHEMBL8938192 0.84 HTR5A (0.32) HTR5A
SCHEMBL9691832 0.81 HTR5A (0.33) HTR5A
SCHEMBL10402771 0.81 HTR5A (0.33) HTR5A
SCHEMBL9008384 0.81 PNMT (0.33) HTR5A
SCHEMBL30349477 0.80 ALDH1A1 (0.40) HTR5A
SCHEMBL30349330 0.80 ALDH1A1 (0.40) HTR5A
SCHEMBL23662479 0.79 KIF11 (0.38)
SCHEMBL8378247 0.78 TDP1 (0.34) TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5534626-A SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST INTERMEDIATES PFIZER INC. (US) 1996-07-09 US disclosed
EP-0510003-B1 PIPERIDINE AND PYRROLIDINE DERIVATIVES PFIZER LTD (GB) 1995-09-27 EP disclosed
US-5410046-A Selective muscarinic receptor antagonists PFIZER INC. (US) 1995-04-25 US disclosed
US-5344835-A Muscarinic receptor antagonists, smooth muscle relaxants, irritable bowel syndrome PFIZER INC. (US) 1994-09-06 US disclosed
US-5302595-A Muscarinic receptor antagonists PFIZER INC. (US) 1994-04-12 US disclosed
US-5231104-A Anticholinergic PFIZER INC. (US) 1993-07-27 US disclosed
US-5219871-A MUSCARINIC RECEPTOR ANTAGONISTS PFIZER INC. (US) 1993-06-15 US disclosed
US-5192765-A Smooth muscle, bowel, bladder and airway diseases PFIZER INC. (US) 1993-03-09 US disclosed
EP-0350309-B1 PIPERIDINE DERIVATIVES Pfizer Limited (GB) 1992-11-11 EP disclosed
EP-0510003-A1 PIPERIDINE AND PYRROLIDINE DERIVATIVES. PFIZER LTD (GB) 1992-10-28 EP disclosed
EP-0438533-A1 MUSCARINIC RECEPTOR ANTAGONISTS Pfizer Limited (GB) 1991-07-31 EP disclosed
WO-1991010650-A1 PIPERIDINE AND PYRROLIDINE DERIVATIVES PFIZER LIMITED (GB) 1991-07-25 WO disclosed
EP-0252005-B1 HYDROGENATED 1-BENZOOXACYCLOALKYL-PYRIDINE CARBOXYLIC-ACID COMPOUNDS CIBA-GEIGY AG (CH) 1991-07-10 EP disclosed
EP-0364123-B1 MUSCARINIC RECEPTOR ANTAGONISTS Pfizer Limited (GB) 1991-06-12 EP disclosed
US-4957928-A NOOTROPIC AGENTS, COGNITION ACTIVATORS CIBA-GEIGY CORPORATION (US) 1990-09-18 US disclosed
WO-1990004583-A1 MUSCARINIC RECEPTOR ANTAGONISTS PFIZER LIMITED (GB) 1990-05-03 WO disclosed
EP-0365093-A1 Muscarinic receptor antagonists PFIZER INC. (US) 1990-04-25 EP disclosed
EP-0364123-A1 Muscarinic receptor antagonists Pfizer Limited (GB) 1990-04-18 EP disclosed
EP-0350309-A1 Piperidine derivatives Pfizer Limited (GB) 1990-01-10 EP disclosed
EP-0252005-A1 Hydrogenated 1-benzooxacycloalkyl-pyridine carboxylic-acid compounds CIBA-GEIGY AG (CH) 1988-01-07 EP disclosed