Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 6/20 | 0.41 |
| ▸ | CCR3 | P51677 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935595 | 0.93 | HRH1 (0.46) | OPRM1OPRD1OPRK1CACNA1FCHRM1 | |
| SCHEMBL8935587 | 0.90 | OPRM1 (0.47) | OPRM1CHRM1DRD4DRD2HRH1 | |
| SCHEMBL8938841 | 0.87 | OPRM1 (0.43) | OPRM1DRD4DRD2DRD3HRH1 | |
| SCHEMBL8938792 | 0.87 | ROCK1 (0.51) | OPRM1OPRD1OPRK1CACNA1FCHRM1 | |
| SCHEMBL8939156 | 0.86 | ROCK1 (0.52) | OPRM1OPRD1OPRK1CACNA1FCHRM1 | |
| SCHEMBL8935590 | 0.84 | MAOB (0.49) | OPRM1OPRK1OPRL1DRD4DRD2 | |
| SCHEMBL8938969 | 0.84 | OPRM1 (0.44) | OPRM1OPRD1OPRK1CACNA1FCHRM1 | |
| SCHEMBL8939119 | 0.84 | OPRM1 (0.46) | OPRM1OPRD1OPRK1CACNA1FCHRM1 | |
| SCHEMBL8935605 | 0.83 | MAOA (0.48) | OPRK1DRD4DRD2DRD3SCN1A | |
| SCHEMBL8935610 | 0.82 | HRH1 (0.43) | DRD4DRD2HRH1CCR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |
| US-20090093518-A1 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093518-A1 | Piperidinyl-substituted isoquinolone derivatives | MYLK2, MYLK, RHOT2 | OPRM1 3345/4885OPRD1 2836/4885OPRK1 2154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.