Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.59 |
| ▸ | IL1RN | P18510 | 1/20 | 0.59 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | PKM | P14618 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CA12 | O43570 | 4/20 | 0.50 |
| ▸ | CA9 | Q16790 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6073362 | 0.77 | CA1 (0.62) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL21914643 | 0.77 | TSHR (0.61) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL9577133 | 0.77 | KEAP1 (0.57) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL7579145 | 0.75 | PKM (0.83) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL25031372 | 0.75 | KEAP1 (1.00) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL7627388 | 0.75 | KEAP1 (0.67) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL114765 | 0.75 | KEAP1 (1.00) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL3617602 | 0.74 | TET2 (0.57) | KEAP1IL1RNERAP1GAAHTT | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL6399560 | 0.73 | KEAP1 (0.95) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL11513007 | 0.73 | KEAP1 (0.95) | KEAP1IL1RNERAP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078968-A2 | MACHINE PERFUSION WITH COMPLEMENT INHIBITORS | LIFELINE SCIENTIFIC, INC. (US) | 2012-06-14 | — | — | WO | disclosed |
| US-5562904-A | Retroviral transduction of cells using soluble complement inhibitors | ALEXION PHARMACEUTICALS, INC. (US) | 1996-10-08 | — | — | US | disclosed |
| US-4369191-A | COMPLEMENT INHIBITION | AMERICAN CYANAMID COMPANY (US) | 1983-01-18 | — | — | US | disclosed |
| US-4369191-A | COMPLEMENT INHIBITION | AMERICAN CYANAMID COMPANY (US) | 1983-01-18 | — | — | US | disclosed |
| US-4369191-A | COMPLEMENT INHIBITION | AMERICAN CYANAMID COMPANY (US) | 1983-01-18 | — | — | US | disclosed |