Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | STAT6 | P42226 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 3/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9223966 | 0.82 | LMNA (0.44) | LMNAKDM4ECYP3A4ABCB11ESR1 | |
| SCHEMBL8939597 | 0.82 | LMNA (0.46) | LMNAKDM4ECYP3A4ABCB11ESR1 | |
| SCHEMBL8939603 | 0.79 | TSHR (0.48) | LMNAKDM4ECYP3A4ABCB11ESR1 | |
| SCHEMBL9125240 | 0.77 | LMNA (0.52) | LMNAKDM4ECYP3A4ABCB11ESR1 | |
| SCHEMBL9123720 | 0.77 | LMNA (0.55) | LMNAKDM4ECYP3A4ABCB11ESR1 | |
| SCHEMBL8939721 | 0.76 | HSD11B1 (0.44) | LMNAKDM4ECYP3A4ABCB11ESR1 | |
| SCHEMBL8939608 | 0.76 | ALDH1A1 (0.44) | LMNAKDM4ECYP3A4ABCB11ESR1 | |
| SCHEMBL8939637 | 0.76 | ALDH1A1 (0.44) | LMNAKDM4ECYP3A4ABCB11ESR1 | |
| SCHEMBL8939658 | 0.76 | ALDH1A1 (0.44) | LMNAKDM4ECYP3A4ABCB11ESR1 | |
| SCHEMBL9125693 | 0.75 | ALDH1A1 (0.62) | LMNAKDM4ECYP3A4ABCB11ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626369-B1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO KK (JP) | 1996-09-18 | — | — | EP | disclosed |
| US-5523464-A | BONE DISORDERS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-06-04 | — | — | US | disclosed |
| EP-0626369-A1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-30 | — | — | EP | disclosed |