Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | TCF4 | P15884 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939600 | 0.87 | LMNA (0.50) | LMNASMN1; SMN2ALDH1A1HPGDPKM | |
| SCHEMBL8939597 | 0.78 | LMNA (0.46) | LMNASMN1; SMN2ALDH1A1HPGDPKM | |
| SCHEMBL8939673 | 0.75 | LMNA (0.50) | LMNASMN1; SMN2ALDH1A1PKMTP53 | |
| SCHEMBL9124828 | 0.72 | MEN1 (0.62) | SMN1; SMN2ALDH1A1HTTTP53NPC1 | |
| SCHEMBL8939608 | 0.72 | ALDH1A1 (0.44) | LMNASMN1; SMN2ALDH1A1HTTMEN1 | |
| SCHEMBL8939671 | 0.72 | ALDH1A1 (0.50) | LMNASMN1; SMN2ALDH1A1HPGDPKM | |
| SCHEMBL8939658 | 0.72 | ALDH1A1 (0.44) | LMNASMN1; SMN2ALDH1A1HTTMEN1 | |
| SCHEMBL8939637 | 0.72 | ALDH1A1 (0.44) | LMNASMN1; SMN2ALDH1A1HTTMEN1 | |
| SCHEMBL8939601 | 0.72 | CA12 (0.50) | LMNASMN1; SMN2ALDH1A1HTTTP53 | |
| SCHEMBL9019620 | 0.72 | KDM4E (0.40) | LMNAALDH1A1PKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626369-B1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO KK (JP) | 1996-09-18 | — | — | EP | disclosed |
| US-5523464-A | BONE DISORDERS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-06-04 | — | — | US | disclosed |
| EP-0626369-A1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-30 | — | — | EP | disclosed |