Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | USP5 | P45974 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939603 | 0.85 | TSHR (0.48) | LMNATSHRMEN1ALDH1A1HTT | |
| SCHEMBL8939721 | 0.80 | HSD11B1 (0.44) | LMNATSHRMEN1ALDH1A1HTT | |
| SCHEMBL8939613 | 0.77 | KMT2A (0.56) | LMNATSHRMEN1ALDH1A1MAPK1 | |
| SCHEMBL8939673 | 0.74 | LMNA (0.50) | LMNATSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL8939658 | 0.72 | ALDH1A1 (0.44) | LMNATSHRMEN1ALDH1A1HTT | |
| SCHEMBL8939637 | 0.72 | ALDH1A1 (0.44) | LMNATSHRMEN1ALDH1A1HTT | |
| SCHEMBL8939608 | 0.72 | ALDH1A1 (0.44) | LMNATSHRMEN1ALDH1A1HTT | |
| SCHEMBL8939645 | 0.71 | KMT2A (0.55) | LMNAMEN1ALDH1A1HTTKMT2A | |
| SCHEMBL9019620 | 0.71 | KDM4E (0.40) | LMNATSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL8939597 | 0.70 | LMNA (0.46) | LMNATSHRMEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626369-B1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO KK (JP) | 1996-09-18 | — | — | EP | disclosed |
| US-5523464-A | BONE DISORDERS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-06-04 | — | — | US | disclosed |
| EP-0626369-A1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-30 | — | — | EP | disclosed |