Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 4/20 | 0.40 |
| ▸ | NNMT | P40261 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30664846 | 0.81 | IKBKB (0.46) | KMT2AATMCASP1NNMTLMNA | |
| SCHEMBL392559 | 0.81 | IKBKB (0.46) | KMT2AATMCASP1NNMTLMNA | |
| SCHEMBL18941668 | 0.81 | KMT2A (0.41) | KMT2AATMCASP1NNMTLMNA | |
| SCHEMBL56617 | 0.80 | SMN1; SMN2 (0.50) | KMT2ACASP1LMNAALDH1A1SLC6A12 | |
| SCHEMBL29378242 | 0.80 | SMN1; SMN2 (0.50) | KMT2ACASP1LMNAALDH1A1SLC6A12 | |
| SCHEMBL671978 | 0.80 | SLC6A12 (0.38) | LMNAALDH1A1SLC6A12MAPTGAA | |
| SCHEMBL29375536 | 0.80 | SLC6A12 (0.38) | LMNAALDH1A1SLC6A12MAPTGAA | |
| SCHEMBL3648999 | 0.79 | NNMT (0.58) | KMT2AATMNNMTLMNAALDH1A1 | |
| SCHEMBL29943583 | 0.79 | KMT2A (0.40) | KMT2AATMCASP1NNMTLMNA | |
| SCHEMBL5190356 | 0.79 | POLB (0.52) | KMT2AATMCASP1NNMTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 279 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12202813-B2 | Process for preparing 6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide | BEIJING INNOCARE PHARMA TECH CO., LTD (CN) | 2025-01-21 | — | — | US | claimed |
| EP-3931182-A1 | PROCESS FOR PREPARING 6- (1-ACRYLOYLPIPERIDIN-4-YL) -2- (4-PHENOXYPHENYL) NICOTINAMIDE | Beijing InnoCare Pharma Tech Co., Ltd. (CN) | 2022-01-05 | — | — | EP | claimed |
| CN-113698342-B | Preparation method of 2, 6-dichloronicotinic acid as key intermediate heterocyclic compound of orbetinib | 南京恒远科技开发有限公司 | 2021-12-31 | — | — | CN | claimed |
| US-20210380555-A1 | PROCESS FOR PREPARING 6-(1-ACRYLOYLPIPERIDIN-4-YL)-2-(4-PHENOXYPHENYL)NICOTINAMIDE | BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) | 2021-12-09 | — | — | US | claimed |
| CN-113698342-A | Preparation method of 2, 6-dichloronicotinic acid as key intermediate heterocyclic compound of orbetinib | 南京恒远科技开发有限公司 | 2021-11-26 | — | — | CN | claimed |
| CN-113454066-A | Process for the preparation of 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide | 北京诺诚健华医药科技有限公司 | 2021-09-28 | — | — | CN | claimed |
| US-12503467-B2 | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors | IDEAYA BIOSCIENCES, INC. (US) | 2025-12-23 | — | — | US | disclosed |
| US-20250381187-A1 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | AMGEN INC. (US) | 2025-12-18 | — | — | US | disclosed |
| US-12440491-B2 | KRAS G12C inhibitors and methods of using the same | AMGEN INC. (US) | 2025-10-14 | — | — | US | disclosed |
| EP-4602041-A1 | HPK1 INHIBITORS AND METHODS OF USE THEREOF | Arcus Biosciences, Inc. (US) | 2025-08-20 | — | — | EP | disclosed |
| US-20250250286-A1 | FUSED PYRIMIDINE DERIVATIVES AS KRAS ONCOPROTEIN INHIBITORS | BETA PHARMA INC (US) | 2025-08-07 | — | — | US | disclosed |
| US-20250163016-A1 | PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | CHENGDU EASTON BIOPHARMACEUTICALS CO., LTD. (CN) | 2025-05-22 | — | — | US | disclosed |
| US-20250084064-A1 | 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-03-13 | — | — | US | disclosed |
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |
| US-5571912-A | Method for the preparation of 5,11-dihydro-6h-dipyrido [3,2-b:2',3'-e][1,4]diazepines | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1996-11-05 | — | — | US | disclosed |
| EP-0482481-A1 | Method for the preparation of 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepines | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1992-04-29 | — | — | EP | disclosed |
| EP-0482481-A1 | Method for the preparation of 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepines | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1992-04-29 | — | — | EP | disclosed |
| US-4100283-A | Growth promoting feed additive oxadiazines | CIBA-GEIGY CORPORATION (US) | 1978-07-11 | — | — | US | disclosed |
| US-4064243-A | Heterocyclic-substituted 1,3,5-oxadiazin-2-one compounds useful for combatting coccidiosis | CIBA-GEIGY CORPORATION (US) | 1977-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250250286-A1 | FUSED PYRIMIDINE DERIVATIVES AS KRAS ONCOPROTEIN INHIBITORS | KRAS, NRAS, HRAS | KMT2A 2575/4885ATM 1843/4885CASP1 2260/4885 |
| US-20250084064-A1 | 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS | SCN8A, SCN2A, SCN1A | KMT2A 1842/4885ATM 4327/4885CASP1 1936/4885 |
| US-20250163016-A1 | PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | KDM1B, KDM1A, EZH2 | KMT2A 44/4885ATM 3831/4885CASP1 1582/4885 |
| US-12202813-B2 | Process for preparing 6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide | NAMPT, NNT, NAPRT | KMT2A 2421/4885ATM 1620/4885CASP1 492/4885 |
| US-20250381187-A1 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | KRAS, NRAS, HRAS | KMT2A 2069/4885ATM 2171/4885CASP1 3637/4885 |
| US-12440491-B2 | KRAS G12C inhibitors and methods of using the same | KRAS, NRAS, HRAS | KMT2A 2069/4885ATM 2171/4885CASP1 3637/4885 |
| US-20210380555-A1 | PROCESS FOR PREPARING 6-(1-ACRYLOYLPIPERIDIN-4-YL)-2-(4-PHENOXYPHENYL)NICOTINAMIDE | NAMPT, NNT, NAPRT | KMT2A 2421/4885ATM 1620/4885CASP1 492/4885 |
| US-12503467-B2 | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors | MAT2B, MAT2A, MAT1A | KMT2A 102/4885ATM 521/4885CASP1 4328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.