Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 4/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.35 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941438 | 0.87 | POLB (0.50) | HTTPOLBAPAF1GRK2APOBEC3G | |
| SCHEMBL8941420 | 0.85 | MIF (0.38) | POLBAPAF1GRK2APOBEC3GMIF | |
| SCHEMBL8941571 | 0.84 | ALOX5 (0.47) | POLBALOX5NPC1 | |
| SCHEMBL8941576 | 0.80 | ALOX5 (0.48) | POLBMIFALOX5NPC1 | |
| SCHEMBL21066131 | 0.79 | HTT (0.49) | HTTPOLBAPAF1GRK2APOBEC3G | |
| SCHEMBL8941751 | 0.73 | ALOX5 (0.53) | ALOX5NPC1 | |
| SCHEMBL10388512 | 0.70 | POLB (0.71) | HTTPOLBAPAF1GRK2APOBEC3G | |
| SCHEMBL21066149 | 0.69 | HTT (0.39) | HTTPOLBAPAF1GRK2APOBEC3G | |
| SCHEMBL7969530 | 0.69 | ALOX5 (0.46) | POLBALOX5 | |
| SCHEMBL7972709 | 0.69 | ALOX5 (0.46) | POLBALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5552424-A | Isoxazolines as antiinflammatory agents | PFIZER INC. (US) | 1996-09-03 | — | — | US | disclosed |