Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941576 | 0.91 | ALOX5 (0.48) | ALOX5TSHRCYP2C19LMNACYP1A2 | |
| SCHEMBL8941571 | 0.87 | ALOX5 (0.47) | ALOX5CYP2C19LMNACYP1A2ALDH1A1 | |
| SCHEMBL8941414 | 0.83 | F10 (0.42) | ALOX5LMNACYP1A2ALDH1A1GAA | |
| SCHEMBL29846490 | 0.78 | TSHR (0.58) | TSHRCYP3A4CYP2C19LMNACYP1A2 | |
| SCHEMBL8941419 | 0.77 | ALOX5 (0.63) | ALOX5TSHRCYP3A4CYP2C19LMNA | |
| SCHEMBL8941420 | 0.76 | MIF (0.38) | ALOX5CYP2C19LMNACYP1A2NPC1 | |
| SCHEMBL8941438 | 0.76 | POLB (0.50) | TSHRCYP3A4CYP2C19LMNACYP1A2 | |
| SCHEMBL10389741 | 0.74 | TSHR (0.59) | TSHRCYP3A4CYP2C19LMNACYP1A2 | |
| SCHEMBL8941440 | 0.73 | HTT (0.47) | ALOX5NPC1 | |
| SCHEMBL25400742 | 0.70 | TSHR (0.58) | TSHRCYP3A4CYP2C19LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6157485-A | — | — | None | — | — | JP | disclosed |
| US-5552424-A | Isoxazolines as antiinflammatory agents | PFIZER INC. (US) | 1996-09-03 | — | — | US | disclosed |
| JP-H06157485-A | NEW ISOXAZOLINE A ANTIINFLAMMATORY AGENT | PFIZER PHARMACEUT CO LTD | 1994-06-03 | — | — | JP | disclosed |