Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.57 |
| ▸ | RORC | P51449 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21315836 | 1.00 | SIGMAR1 (0.57) | SIGMAR1RORCLMNAPOLBALDH1A1 | |
| SCHEMBL25154604 | 1.00 | SIGMAR1 (0.57) | SIGMAR1RORCLMNAPOLBALDH1A1 | |
| SCHEMBL10681973 | 0.89 | SIGMAR1 (0.55) | SIGMAR1LMNAPOLBALDH1A1MEN1 | |
| SCHEMBL123695 | 0.85 | SIGMAR1 (0.61) | SIGMAR1LMNAPOLBALDH1A1GAA | |
| SCHEMBL8408488 | 0.84 | GBA1 (0.48) | SIGMAR1RORCPOLBALDH1A1KMT2A | |
| SCHEMBL25154296 | 0.84 | MC4R (0.49) | SIGMAR1ALDH1A1 | |
| SCHEMBL25154556 | 0.84 | SIGMAR1 (0.47) | SIGMAR1LMNAALDH1A1KMT2A | |
| SCHEMBL25154734 | 0.84 | SIGMAR1 (0.59) | SIGMAR1ALDH1A1 | |
| SCHEMBL25154270 | 0.84 | SIGMAR1 (0.59) | SIGMAR1ALDH1A1 | |
| SCHEMBL65364 | 0.83 | SIGMAR1 (0.78) | SIGMAR1LMNAPOLBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240216361-A1 | ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B V (US) | 2024-07-04 | — | — | US | disclosed |
| US-20230277527-A1 | ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2023-09-07 | — | — | US | disclosed |
| WO-2023064768-A1 | G-PROTEIN-COUPLED RECEPTOR REGULATORS AND METHODS OF USE THEREOF | BAYLOR COLLEGE OF MEDICINE (US) | 2023-04-20 | — | — | WO | disclosed |
| CN-110139652-B | ROR-gamma modulators | 爱思凯利尔生物科学私人有限责任公司 | 2022-10-11 | — | — | CN | disclosed |
| EP-3532062-B1 | ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES BV (US) | 2022-07-20 | — | — | EP | disclosed |
| US-20220175765-A1 | ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2022-06-09 | — | — | US | disclosed |
| US-20210069182-A1 | ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-03-11 | — | — | US | disclosed |
| US-10905687-B2 | Substituted piperazines as ROR-gamma modulators | ESCALIER BIOSCIENCES B.V. (US) | 2021-02-02 | — | — | US | disclosed |
| US-20190269674-A1 | ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES, BV (US) | 2019-09-05 | — | — | US | disclosed |
| US-9133206-B2 | Benzodiazepine and pyridodiazepine derivatives | ABBVIE INC. (US) | 2015-09-15 | — | — | US | disclosed |
| US-20140163014-A1 | BENZODIAZEPINE AND PYRIDODIAZEPINE DERIVATIVES | ABBVIE INC. | 2014-06-12 | — | — | US | disclosed |
| US-8673896-B2 | Benzodiazepine and pyridodiazepine derivatives | ABBVIE INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156612-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | SIGMAR1 3163/4885RORC 1171/4885LMNA 1785/4885 |
| US-20230277527-A1 | ROR-GAMMA MODULATORS | RORB, RORC, RORA | SIGMAR1 1215/4885RORC 2/4885LMNA 2990/4885 |
| US-20240216361-A1 | ROR-GAMMA MODULATORS | RORB, RORC, RORA | SIGMAR1 1215/4885RORC 2/4885LMNA 2990/4885 |
| US-20210069182-A1 | ROR-GAMMA MODULATORS | RORB, RORC, RORA | SIGMAR1 1215/4885RORC 2/4885LMNA 2990/4885 |
| US-10905687-B2 | Substituted piperazines as ROR-gamma modulators | RORC, RORA, RORB | SIGMAR1 477/4885RORC 1/4885LMNA 2539/4885 |
| US-20220175765-A1 | ROR-GAMMA MODULATORS | RORB, RORC, RORA | SIGMAR1 1215/4885RORC 2/4885LMNA 2990/4885 |
| US-20140163014-A1 | BENZODIAZEPINE AND PYRIDODIAZEPINE DERIVATIVES | GABRA3, GABRB3, GABRA1 | SIGMAR1 149/4885RORC 258/4885LMNA 1090/4885 |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | SIGMAR1 3163/4885RORC 1171/4885LMNA 1785/4885 |
| US-20190269674-A1 | ROR-GAMMA MODULATORS | RORB, RORC, RORA | SIGMAR1 1215/4885RORC 2/4885LMNA 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.