Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL334587 | 0.82 | MAPT (0.40) | CYP2C19CYP1A2HSD17B10MAPT | |
| SCHEMBL10362321 | 0.79 | EIF2AK4 (0.35) | KMT2AMAPT | |
| SCHEMBL7660403 | 0.77 | SIGMAR1 (0.48) | KDM4EALDH1A1 | |
| SCHEMBL7801902 | 0.77 | L3MBTL1 (0.54) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5265583 | 0.76 | CACNA1A (0.56) | KDM4EALDH1A1RAB9ASLC6A2SLC6A4 | |
| SCHEMBL6925601 | 0.76 | MEN1 (0.59) | KDM4EALDH1A1PKMRAB9AMEN1 | |
| SCHEMBL4182909 | 0.75 | SMN1; SMN2 (0.45) | KDM4EALDH1A1RAB9ACYP2C19CYP2D6 | |
| SCHEMBL7241545 | 0.74 | BCHE (0.36) | KDM4E | |
| SCHEMBL3407039 | 0.73 | ALDH1A1 (0.52) | KDM4EALDH1A1PKMMEN1KMT2A | |
| SCHEMBL191625 | 0.72 | HRH4 (0.39) | KDM4EALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110041309-B | 2-carboxypiperazine-linked tacrine-8-amino (hydroxy) quinoline derivative and preparation and application thereof | 广东工业大学 | 2022-01-28 | — | — | CN | disclosed |
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |