Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8945951 | 0.98 | ADORA2B (0.31) | ADORA2B | |
| SCHEMBL8945994 | 0.84 | HSD17B10 (0.34) | ADORA2BHRH4 | |
| SCHEMBL8946148 | 0.81 | ADORA2B (0.33) | ADORA2BOPRM1OPRK1HRH4 | |
| SCHEMBL8945923 | 0.81 | HRH4 (0.35) | HRH4 | |
| Hydrochloric Acid SCHEMBL8945921 | 0.80 | HRH4 (0.34) | HRH4 | |
| Hydrochloric Acid SCHEMBL8945865 | 0.80 | ADORA2B (0.32) | ADORA2BOPRM1OPRK1 | |
| SCHEMBL8946091 | 0.79 | SLC6A2 (0.38) | HRH4 | |
| SCHEMBL8945861 | 0.79 | SMN1; SMN2 (0.32) | ADORA2B | |
| Hydrochloric Acid SCHEMBL8945737 | 0.78 | SLC6A2 (0.37) | HRH4 | |
| SCHEMBL8946123 | 0.78 | OPRM1 (0.31) | ADORA2BOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510346-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-04-23 | — | — | US | claimed |
| US-5510346-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5292760-A | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0322582-A2 | 4-Heteroaryl-1,3-Benzodiazepines and 2-substituted-alpha-(heteroaryl)benzeneethanamines, a process for their preparation and their use us medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-07-05 | — | — | EP | disclosed |