Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946005 | 0.85 | ALOX5 (0.32) | ALOX5KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL8945840 | 0.85 | ALOX5 (0.35) | ALOX5KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL8946039 | 0.83 | CXCR1 (0.32) | ALOX5KMT2ACXCR1CXCR2 | |
| SCHEMBL8945946 | 0.83 | KDM4E (0.38) | KMT2AMEN1CYP2D6HTT | |
| SCHEMBL9425099 | 0.82 | ALOX5 (0.33) | ALOX5KMT2ACXCR1CXCR2 | |
| Hydrochloric Acid SCHEMBL8945763 | 0.81 | CXCR1 (0.32) | KMT2ACXCR1CXCR2 | |
| SCHEMBL9425592 | 0.74 | KDM4E (0.31) | ALDH1A1CXCR1CXCR2 | |
| SCHEMBL8945969 | 0.73 | OPRM1 (0.44) | NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL8945768 | 0.72 | HSPA5 (0.38) | KMT2AMEN1ALDH1A1MAPTCYP2D6 | |
| Hydrochloric Acid SCHEMBL8946070 | 0.71 | MAPT (0.39) | KMT2AMEN1ALDH1A1MAPTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292760-A | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | claimed |
| US-5510346-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5292760-A | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0322582-A2 | 4-Heteroaryl-1,3-Benzodiazepines and 2-substituted-alpha-(heteroaryl)benzeneethanamines, a process for their preparation and their use us medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-07-05 | — | — | EP | disclosed |