SCHEMBL8946066

SCHEMBL8946066

Cc1ccsc1C(Cc1ccccc1N(C)C)N(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.33
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8946005 0.85 ALOX5 (0.32) ALOX5KMT2A
SCHEMBL8945876 0.83 ALOX5 (0.35) ALOX5KMT2A
SCHEMBL8945773 0.81 CXCR1 (0.33) ALOX5KMT2A
SCHEMBL8945888 0.70 KRAS (0.33) ALOX5
SCHEMBL8945985 0.69 RECQL (0.36) ALOX5KMT2A
SCHEMBL8945840 0.69 ALOX5 (0.35) ALOX5KMT2A
SCHEMBL8946090 0.69 ALOX5 (0.39) ALOX5KMT2A
SCHEMBL8946039 0.68 CXCR1 (0.32) ALOX5KMT2A
SCHEMBL8945946 0.68 KDM4E (0.38) KMT2A
SCHEMBL8946088 0.68 ALOX5 (0.41) ALOX5KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5510346-A ANTIDEPRESSANTS, ANTIANXIETY AGENTS HOECHST MARION ROUSSEL, INC. (US) 1996-04-23 US disclosed
US-5292760-A 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1994-03-08 US disclosed