Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 6/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946733 | 0.86 | LPAR1 (0.46) | PYGLMAPK14TAS1R3TAS1R1CYP2C9 | |
| SCHEMBL8946560 | 0.83 | ANPEP (0.41) | PYGLCNR1S1PR4 | |
| SCHEMBL27429743 | 0.76 | LMNA (0.37) | MAPK14KMT2ACNR1PTGESSMN1; SMN2 | |
| SCHEMBL8946926 | 0.76 | NTRK1 (0.53) | KMT2AS1PR4 | |
| SCHEMBL8946727 | 0.76 | LMNA (0.43) | PYGLKMT2ACNR1S1PR4 | |
| SCHEMBL8946528 | 0.74 | LMNA (0.41) | PYGLCNR1S1PR4 | |
| SCHEMBL8946542 | 0.74 | ANPEP (0.40) | CNR1S1PR4 | |
| SCHEMBL8946397 | 0.74 | S1PR4 (0.39) | MAPK14CNR1S1PR4 | |
| SCHEMBL8946580 | 0.73 | NPC1 (0.41) | KMT2ACNR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8946576 | 0.73 | L3MBTL1 (0.51) | KMT2ACYP2C9CNR1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500424-A | ENZYME INHIBITORS | NIHON NOHYAKU CO., LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0638557-A1 | N-phenylpyri(mi)dine-N'-phenyl-urea derivatives, their preparation and their use as ACAT inhibitors | NIHON NOHYAKU CO., LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |