Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | MTOR | P42345 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946575 | 0.92 | MEN1 (0.43) | ALDH1A1MAPTTDP1LPAR1PTPN11 | |
| SCHEMBL8946495 | 0.91 | MEN1 (0.42) | ALDH1A1MAPTTDP1LPAR1PTPN11 | |
| SCHEMBL8946790 | 0.90 | CDK9 (0.42) | MAPTLCKCYP1A2CYP3A4LPAR1 | |
| SCHEMBL8946520 | 0.88 | PIK3R1 (0.43) | PIK3CAPIK3R1ALDH1A1CNR2MTOR | |
| SCHEMBL8823091 | 0.81 | ALDH1A1 (0.42) | ALDH1A1CNR2MTORGAAMAPT | |
| SCHEMBL8946359 | 0.81 | NTRK1 (0.53) | LPAR1 | |
| SCHEMBL8946668 | 0.81 | LPAR1 (0.47) | LPAR1 | |
| SCHEMBL8946569 | 0.79 | LPAR1 (0.46) | MAPK14LPAR1 | |
| SCHEMBL8946528 | 0.79 | LMNA (0.41) | ALDH1A1MAPTPTPN11 | |
| SCHEMBL8946618 | 0.78 | L3MBTL1 (0.51) | L3MBTL1CYP1A2CYP2C9CYP2C19LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500424-A | ENZYME INHIBITORS | NIHON NOHYAKU CO., LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0638557-A1 | N-phenylpyri(mi)dine-N'-phenyl-urea derivatives, their preparation and their use as ACAT inhibitors | NIHON NOHYAKU CO., LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |