Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056937 | 0.92 | TP53 (0.46) | TP53ADORA1ADORA3ADORA2AALDH1A1 | |
| SCHEMBL9507591 | 0.92 | FNTA (0.39) | TP53ADORA1ADORA3ADORA2AMAPT | |
| SCHEMBL8957164 | 0.87 | TP53 (0.40) | TP53ALDH1A1MAPTLMNATHRB | |
| SCHEMBL9509859 | 0.84 | TP53 (0.39) | TP53ADORA1ADORA3ADORA2AALDH1A1 | |
| SCHEMBL7056869 | 0.83 | TP53 (0.45) | TP53ALDH1A1MAPT | |
| SCHEMBL7056939 | 0.81 | PTGES (0.41) | — | |
| SCHEMBL9508507 | 0.79 | TP53 (0.36) | TP53ADORA1ADORA3ADORA2AALDH1A1 | |
| SCHEMBL8957190 | 0.79 | TP53 (0.38) | TP53ADORA1ADORA3ADORA2A | |
| Hydrochloric Acid SCHEMBL9530574 | 0.78 | MAPT (0.41) | TP53ADORA1ADORA3ADORA2AALDH1A1 | |
| SCHEMBL8971303 | 0.77 | TP53 (0.44) | TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536262-A4 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORP (US) | 1996-08-14 | — | — | EP | disclosed |
| EP-0561876-A1 | USE OF ANGIOTENSIN II RECEPTOR ANTAGONISTS IN THE TREATMENT OF ATHEROMA. | SMITHKLINE BEECHAM PLC (GB) | 1993-09-29 | — | — | EP | disclosed |
| EP-0561901-A1 | USE OF ANGIOTENSIN II RECEPTOR ANTAGONISTS IN THE TREATMENT OF DIABETIC RETINOPATHY | SMITHKLINE BEECHAM PLC (GB) | 1993-09-29 | — | — | EP | disclosed |
| EP-0536262-A1 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-14 | — | — | EP | disclosed |