Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL8958146 | 1.00 | ALDH1A1 (0.41) | ALDH1A1TP53NPC1JAK2RAB9A | |
| Potassium Ion SCHEMBL8958393 | 1.00 | ALDH1A1 (0.41) | ALDH1A1TP53NPC1JAK2RAB9A | |
| Potassium Ion SCHEMBL8957909 | 1.00 | ALDH1A1 (0.41) | ALDH1A1TP53NPC1JAK2RAB9A | |
| Potassium Ion SCHEMBL8957905 | 0.94 | NR1H2 (0.35) | ALDH1A1TP53CES2CES1CNR2 | |
| SCHEMBL8958180 | 0.87 | ALDH1A1 (0.44) | ALDH1A1TP53NPC1JAK2RAB9A | |
| SCHEMBL6550713 | 0.75 | ESR1 (0.44) | ALDH1A1TP53ESR1 | |
| SCHEMBL9798892 | 0.74 | KCNH2 (0.47) | ALDH1A1TP53NPC1JAK2RAB9A | |
| SCHEMBL6567779 | 0.72 | ALDH1A1 (0.50) | ALDH1A1TP53NPC1JAK2RAB9A | |
| SCHEMBL6567311 | 0.72 | ALDH1A1 (0.50) | ALDH1A1TP53NPC1JAK2RAB9A | |
| SCHEMBL6566239 | 0.72 | ALDH1A1 (0.50) | ALDH1A1TP53NPC1JAK2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535842-B1 | Benzofuranones | ZENECA LTD (GB) | 1996-01-10 | — | — | EP | disclosed |
| US-5389597-A | For dye diffusion thermal transfer printing | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-02-14 | — | — | US | disclosed |
| US-5268490-A | With indan-1,3-dione and aminobenzene ring | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-07 | — | — | US | disclosed |
| EP-0535842-A1 | Benzofuranones | ZENECA LIMITED (GB) | 1993-04-07 | — | — | EP | disclosed |