SCHEMBL8959276

SCHEMBL8959276

CC(C)c1ccccc1S(=O)[O-].CC(C)c1ccccc1S(=O)[O-].[Ca+2]

nearest known ligand 0.49

Known targets — ChEMBL curated mechanism

GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 known ✓ P14867 3/20 0.40
GABRB2 known ✓ P47870 2/20 0.40
GABRG2 known ✓ P18507 2/20 0.37
GABRB3 known ✓ P28472 2/20 0.37
GABRB1 known ✓ P18505 1/20 0.37
PTGS1 known ✓ P23219 1/20 0.37
GABRA5 known ✓ P31644 1/20 0.37
GABRA3 known ✓ P34903 1/20 0.37
GABRA2 known ✓ P47869 1/20 0.37
GABRA4 known ✓ P48169 1/20 0.37
GABRA6 known ✓ Q16445 1/20 0.37
CYP3A4 P08684 2/20 0.49
ALDH1A1 P00352 1/20 0.49
CYP2C19 P33261 1/20 0.49
LMNA P02545 2/20 0.37
KMT2A Q03164 1/20 0.37
FAAH O00519 2/20 0.37
CA1 P00915 2/20 0.37
CA2 P00918 2/20 0.37
CYP1A2 P05177 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9843874 0.77 CYP3A4 (0.54) CYP3A4ALDH1A1CYP2C19GABRA1GABRB2
SCHEMBL8958887 0.77 GABRA1 (0.43) CYP3A4ALDH1A1CYP2C19GABRA1GABRB2
SCHEMBL30717958 0.77 CYP3A4 (0.54) CYP3A4ALDH1A1CYP2C19GABRA1GABRB2
SCHEMBL8959279 0.75 CYP3A4 (0.53) CYP3A4ALDH1A1CYP2C19GABRA1GABRB2
SCHEMBL27872592 0.75 CYP3A4 (0.53) CYP3A4ALDH1A1CYP2C19GABRA1GABRB2
SCHEMBL11859111 0.71 G6PD (0.42) ALDH1A1CA2G6PD
SCHEMBL3147532 0.71 TSHR (0.41) CYP3A4ALDH1A1CA1CA2CYP1A2
SCHEMBL30679046 0.71 TSHR (0.41) CYP3A4ALDH1A1CA1CA2CYP1A2
SCHEMBL31204330 0.71 GABRA1 (0.60) CYP3A4ALDH1A1GABRA1GABRB2LMNA
Potassium Ion SCHEMBL11327766 0.71 FABP3 (0.35) CYP3A4ALDH1A1CYP2C19LMNACA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019203356-A1 ADHESIVE COMPOSITION FOR DENTAL USE クラレノリタケデンタル株式会社 2019-10-24 WO disclosed
US-5486544-A AROMATIC SULFINATE POLYMERIZATION CATALYST KURARAY CO., LTD. (JP) 1996-01-23 US disclosed
EP-0408357-B1 Polymerizable composition KURARAY CO (JP) 1994-06-01 EP disclosed
EP-0408357-A2 Polymerizable composition KURARAY CO., LTD. (JP) 1991-01-16 EP disclosed