Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7273886 | 0.94 | HTR3E (0.42) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Maleic Acid SCHEMBL7273875 | 0.94 | HTR3E (0.42) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7267047 | 0.83 | HTR3A (0.66) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9681702 | 0.77 | MTNR1A (0.41) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9730191 | 0.76 | HTR3A (0.37) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL9730401 | 0.75 | HTR3A (0.38) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Cadaverine Tartrate SCHEMBL7429503 | 0.74 | MTNR1A (0.37) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7286830 | 0.70 | HTR3A (0.72) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7277463 | 0.70 | HTR3A (0.54) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7267311 | 0.70 | HTR3A (0.62) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530008-A | USEFUL FOR TREATING ANXIETY DISORDER AND AGORAPHOBIA | SANDOZ LTD. (CH) | 1996-06-25 | — | — | US | claimed |
| EP-0422154-B1 | THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS | SANDOZ AG (AT) | 1993-12-01 | — | — | EP | claimed |
| JP-2104585-A | — | — | None | — | — | JP | disclosed |
| US-5530008-A | USEFUL FOR TREATING ANXIETY DISORDER AND AGORAPHOBIA | SANDOZ LTD. (CH) | 1996-06-25 | — | — | US | disclosed |
| EP-0422154-B1 | THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS | SANDOZ AG (AT) | 1993-12-01 | — | — | EP | disclosed |
| US-5026722-A | Antagonists of 5-hydroxytryptamine | GLAXO GROUP LIMITED (GB) | 1991-06-25 | — | — | US | disclosed |
| EP-0422154-A1 | THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS. | SANDOZ AG (AT) | 1991-04-17 | — | — | EP | disclosed |
| WO-1990012569-A1 | THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS | SANDOZ AG (CH) | 1990-11-01 | — | — | WO | disclosed |
| JP-H02104585-A | INDOLE DERIVATIVE | GLAXO GROUP LTD | 1990-04-17 | — | — | JP | disclosed |